Abstract Background: Cardiovascular structural/functional changes caused by COVID-19 may be related to the presence of heart failure (HF), especially in children and adolescents, as the SARS-CoV-2 virus invades cardiomyocytes, leading to cardiac dysfunction. Objective: To assess the mechanism by which COVID-19 becomes a risk factor for the development of HF in children and adolescents. Methods: This was a systematic literature review of articles indexed in PubMed, BVS and SciELO, following the PRISMA recommendations. DeCS/MeSH descriptors were used in the search. […]

Abstract Cardiomyopathies constitute a heterogeneous group of diseases with varying etiologies and clinical presentation. Advances in genetic testing have made it possible to establish genotype-phenotype relationships, determine prognosis, and choose specific treatments in the pediatric population. Therefore, the objective of this review is to assist clinical reasoning and underscore the importance of etiological diagnosis in different disease phenotypes.

Since the emergence of the novel coronavirus 2019 disease (COVID-19), cardiovascular impairment and alterations in cardiology laboratory tests suggestive of myocardial injury, even in patients without cardiovascular symptoms, have been observed in hospitalized children and adults.– Epidemiological data from China have suggested that cardiac injury may occur in 19% to 28% of hospitalized patients with COVID-19. Several factors seem to contribute to myocardial damage, and potential mechanisms of injury include: hypoxic injury, stress cardiomyopathy, ischemic lesion caused by cardiac microvascular […]

Myocardial inflammation, COVID-19, and HFpEF Myocardial inflammation is widely considered to be one of the main factors in the development of heart failure (HF). It is believed that persistent myocardial inflammation plays a central role in the development of adverse left ventricular remodeling after myocardial infarction, as well as in the pathogenesis of dilated cardiomyopathy and heart failure with preserved ejection fraction (HFpEF). – In May 2020, Tavazzi et al. reported the first case of acute cardiac injury with the […]