Abstract Background: Doxorubicin (DOXO) has been used to induce dilated cardiomyopathy (DCM) in experimental models. Objective: To analyze cardiac changes after DOXO infusion and define the most effective protocol to reproduce an experimental model of DCM. Methods: Male Wistar rats were divided into 4 groups and received increasing cumulative doses of DOXO (at a rate of 2 mg/kg/week) or saline solution: the control group (CTR) received saline solution, Group D-8 received a total infusion of 8 mg/kg, Group D-12 received […]