The physician is faced with a septuagenarian patient with chronic heart failure (HF) of severe ischemic etiology. She progresses with a major hemorrhagic complication after attempted percutaneous revascularization. In spite of volume compensation, she shows signs of respiratory infection, and, notwithstanding adequate antibiotic therapy, she continues to deteriorate clinically with signs of hypoperfusion, albeit with borderline blood pressure levels. Would indication of invasive hemodynamic monitoring be scientifically associated with reduced clinical outcomes in this case? Acute clinical syndromes imply a […]

Abstract Heart failure with preserved ejection fraction (HFpEF) is a syndrome in which there is clinical evidence of heart failure (HF), left ventricle ejection fraction (LVEF) ≥50%, and evidence of diastolic dysfunction and/or structural cardiac changes. The pathophysiology of HF with preserved LVEF is related to the primary morbidities responsible for cardiac and vascular aggression via a chronic proinflammatory state involving the endothelium. Currently, the foundation of management of HFpEF rests on 5 pillars: control of circulatory congestion, management of […]