Introduction The many processes that contribute to age-related diseases include Harman’s free-radical telomere shortening, inflammaging, and Medewar’s mutation accumulation theory, especially in hematological malignancies., As we age, hematopoietic stem cells may acquire mutations that modulate their function, proliferation, or survival, thus expanding the pool of mutated cells in blood, a process termed clonal hematopoiesis (CH). With the addition of cooperating mutations, CH cells may progress to myelodysplastic syndrome and acute myeloid leukemia at rates ranging from 0.5 to 1% per […]