ABC Heart Fail Cardiomyop 2022; 2(2): 152-156
Cognitive Frailty and Depressive Symptoms in Heart Transplant Candidates: Rational and Study Design
France Matos de Oliveira
, Erika Tiemi Ikeda
, Luis Fernando Bernal da Costa Seguro
, Mônica Samuel Avila
, Iascara Wozniak de Campos
, Marcus Vinicius B. Santos
, Maria Ignez Zanetti Feltrim
, Silvia Helena Gelas Lage
, Edimar Alcides Bocchi
, Victor Sarli Issa
, Miguel Morita Fernandes-Silva, Fábio Antônio Gaiotto
, Fernando Bacal
, Fabiana Goulart Marcondes-Braga
, Sandrigo Mangini
Abstract
Background:
Patients with advanced heart disease have impaired cognitive abilities and higher probability of depressive symptoms. These factors contribute to negative outcomes of treatment, such as the development of comorbidities, higher hospitalization and mortality rates, poor treatment compliance and self-care, and decrease in quality of life and functionality.
Objective:
To describe the prevalence and to evaluate the impact of cognitive frailty in patients in the waiting list of heart transplantation, with death while waiting transplantation and priority transplantation as clinical outcomes.
Methods:
Longitudinal, prospective study evaluating cognitive frailty in 150 patients with advanced heart failure referred to transplantation in a hospital in Sao Paulo. Volunteers older than 18 years of age, hospitalized or in outpatient care, in the waiting list of transplantation will be considered eligible and will be assess within one month after being included in the waitlist. Cognitive performance will be assessed using the Montreal Cognitive Assessment and the battery of neuropsychological test Wechsler Abbreviated Scale of Intelligence (WASI). The symptoms of depression will be assessed by the Beck Depression Inventory.
Results:
The study will allow to describe the prevalence of cognitive frailty and its relationship with treatment outcomes in a Brazilian population.
Conclusion:
Data from this study will allow the analysis of associations between cognitive profile and severity of heart failure in patients referred to transplantation and their effects on clinical outcomes.
Keywords: Cognitive Frailty; Heart Failure; Heart Transplant
483
