ABC Heart Fail Cardiomyop 2021; 1(2): 112-114
New Paradigms in Cardiac Amyloidosis: The Current Experience of the Northeast Region of Brazil
Tonnison Silva
, Carlos Eduardo Lucena Montenegro
, Marcelo Dantas Tavares de Melo
, Luiz Ritt
, André Luiz Cerqueira Almeida
Cardiac amyloidosis (CA) is a severe and progressive infiltrative disease caused by the deposition of amyloid fibrils, with poor prognosis and limited therapeutic options. It can occur due to rare genetic variants or as a consequence of acquired conditions. Thanks to advances in imaging techniques and the possibility of obtaining non-invasive diagnosis, we now know that CA would perhaps be better classified as an underdiagnosed disease rather than as a rare one. –
González-Lopez et al. demonstrated that, in a series of 120 patients with preserved ejection fraction heart failure, 13.3% had a diagnosis of transthyretin-associated amyloid cardiomyopathy (ATTR-CM). In patients with aortic stenosis, we found a prevalence of around 15% of ATTR-CM, and, in necropsy studies, amyloid protein deposition was found in 25% of patients over 85 years old, which shows the importance of this diagnosis in the spectrum of myocardial diseases.
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Keywords: Amyloidosis; Brazil; Prealbumin
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