Resistance to Loop Diuretics: How to Address it in the Current Scenario?

Savaris, Simone L.; Andrade, Fernanda Almeida; Schwartzmann, Pedro V.

ABC Heart Fail Cardiomyop 2023; 3(2): e20230090

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Resistance to Loop Diuretics: How to Address it in the Current Scenario?

Simone L. Savaris , Fernanda Almeida Andrade , Pedro V. Schwartzmann

DOI: 10.36660/abchf.20230090

Persistent congestion despite the use of loop diuretics (LD) is one of the most important challenges in the management of acute heart failure (HF) and is associated with a worse prognosis. One of the main reasons for this persistence in congestion is resistance to LD, which can be defined as a reduction in sensitivity to diuretics, with reduced natriuresis and diuresis and limitation of reaching euvolemia – LD can reach up to 1/3 of patients admitted for acute HF and independently increases the risk of death by 1.37 times.1-3