Heart failure (HF) is one of the leading causes of death, hospitalization, and rehospitalization worldwide. In spite of advances in treatment with new medications, devices, and heart transplantation, the condition is still associated with significant morbidity and mortality.1 One factor that likely contributes to this fact is the difficulty in titrating doses of drugs targeted at treating HF.2
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Treatment of Heart Failure Based on Natriuretic Peptide Levels: A Question That Has Yet to be Solved?
MontenegroCEL, GomesTQM, LyraACAS, NascimentoJS, DiasLA. Treatment of Heart Failure Based on Natriuretic Peptide Levels: A Question That Has Yet to be Solved?. ABC Heart Fail Cardiomyop 2022;2(1):80-5.
Montenegro,Carlos Eduardo Lucena; Gomes,Taciana Queiroz Medeiros; Lyra,Ana Carla Alves de Souza; Nascimento,Joyce Santana do; Dias,Luana do Amaral. Treatment of Heart Failure Based on Natriuretic Peptide Levels: A Question That Has Yet to be Solved?. ABC Heart Fail Cardiomyop, v. 2, n. 1, p. 80-85, Apr. 2022.
Montenegro,C.E.L., Gomes,T.Q.M., Lyra,A.C.A.S., Nascimento,J.S. , & Dias,L.A. (2022). Treatment of Heart Failure Based on Natriuretic Peptide Levels: A Question That Has Yet to be Solved?. ABC Heart Fail Cardiomyop,2(1), 80-85.
Montenegro,Carlos Eduardo Lucena and Gomes,Taciana Queiroz Medeiros and Lyra,Ana Carla Alves de Souza and Nascimento,Joyce Santana do and Dias,Luana do Amaral. Treatment of Heart Failure Based on Natriuretic Peptide Levels: A Question That Has Yet to be Solved?. ABC Heart Fail Cardiomyop [online]. 2022, vol. 2, n. 1, [cited 2025-09-21], pp.80-85. Available from: <https://www.abcheartfailure.org/article/treatment-of-heart-failure-based-on-natriuretic-peptide-levels-a-question-that-has-yet-to-be-solved/>. ISSN .
Figure 1
– NT-proBNP and BNP synthesis pathways from proBNP. Adapted from Kim et al.8