ABC Heart Fail Cardiomyop 2023; 3(1): e20230043

Brazilian Scientific Production about Cardiomyopathies: A Review from 2010 to 2022

Even Edilce Mol, Sarah Fagundes Grobe , Luis Eduardo Paim Rohde , Lídia Ana Zytynski Moura

DOI: 10.36660/abchf.20230043

By definition, myocardiopathies or cardiomyopathies (CM) are heart muscle diseases that cause structural and functional myocardial abnormalities in the absence of coronary artery disease, hypertension, valvular disease, and congenital heart disease.^,

CM constitute a very heterogeneous group of heart diseases and are one of the leading causes of death either from end-stage heart failure or sudden death due to arrythmias. According to the phenotype, CM may be classified into hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and left ventricular noncompaction, where there may overlap of phenotypes. Each phenotype is then subclassified into: genetic origin (familial), non-genetic (non-familial), and mixed, with the genetic form accounting for most of the cases. According to the statement of American College of Medical Genetics and Genomics, of the 59 genes mentioned in the document, 30 (51%) had cardiovascular phenotypes, and 16 (27%) included CM phenotypes. Non-genetic CM may be caused by infections, autoimmune diseases, and endogenous or exogenous myocardial toxicity, whereas genetic CM may be caused by a variety of known mutations and others under study.

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